Endometrial Scratching Prior to Controlled Ovarian Stimulation (COH) in Women Undergoing In-vitro Fertilization With Previous IVF Failure (ESICOHF)

Mansoura University

Status and phase: Completed; Early Phase 1

Conditions: Infertility

Treatments: Procedure: scratching; Procedure: A PLACEBO PROCEDURE

Study type: Interventional

Funder types: Other

Identifiers

NCT01245309

AG1001

Details and patient eligibility

About

Scratching the linning of the womb before IVF cycle could increase the chances of having a baby after an IVF cycle.

Full description

All women with history of RIF (as defined by ESHRE) and who wish to undertake another assisted conception treatment cycle are invited to participate in the trial. Women will be randomised to two arms; one undergoing endometrial sampling and control. Women in the experimental arm will be subjected to endometrial scrapping with Pipelle biopsy catheter two times; on days 21 and 26 of the cycle prior to the IVF index cycle and after initiation of the GnRHa in the long agonist protocol. Women in the control group will undergo a placebo procedure using the uterine sound on the same days of the cycle like women in the intervention group.

Enrollment: 500 patients

Sex: Female

Ages: Under 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

WOMEN WITH PREVIOUS IVF FAILURE UNDERGOING IVF TREATMENT

Exclusion criteria

• WOMEN>40 YEARS OLD WOMEN UNDERGOING THEIR FIRST IVF TREATMENT CYCLE

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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500 participants in 2 patient groups, including a placebo group

scratching

Experimental group

Description:

endometrial scratching prior ivf cycle

Treatment:

Procedure: scratching

Procedure: A PLACEBO PROCEDURE

PLACEBO

Placebo Comparator group

Description:

PLACEBO PROCEDURE

Treatment:

Procedure: A PLACEBO PROCEDURE