Endometrial Volume and Sub-endometrial Vascularity as Predictors of In-vitro Fertilization Success

Cairo University (CU)

Status: Completed

Conditions: Reproductive Techniques, Assisted

Treatments: Drug: GnRH agonist; Other: 3 D ultrasound and Doppler examination

Study type: Observational

Funder types: Other

Identifiers

NCT02381821

127

Details and patient eligibility

About

100 patients aged 21-40 years old, diagnosed as primary or secondary infertility These patients are then assigned to receive ICSI treatment (ovulation induction, . They undergo a 3D vaginal ultrasound before treatment to measure the junctional zone thickness and followed up after treatment to determine the rate of implantation.

Intervention(s) All patients will undergo 3D ultrasound to measure the thickness of the junctional zone at day 21 of the cycle.

Full description

100 patients aged 21-40 years old, diagnosed as primary or secondary infertility due to the following causes of infertility; ( Pelvic Inflammatory disease, dysovulation , tubal infertility, unexplained infertility, combined infertility or due to male factor ). These patients are then assigned to receive fertility treatment (ICSI) They undergo a 3D vaginal ultrasound before treatment to measure the junctional zone thickness and followed up after treatment to determine the rate of implantation.

Intervention(s) All patients will undergo 3D ultrasound to measure the thickness of the junctional zone at day 21 of the cycle.

Enrollment: 82 patients

Sex: Female

Ages: 19 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• A normal transvaginal ultrasound is defined as having no visible intracavitary pathology (e.g. submucous myomas, polyps or septa) and was be performed in the follicular phase of the menstrual cycle. Intramural myomas without impression or deformation of the uterine cavity were incorporated in the definition of a normal ultrasound

Exclusion criteria

• Exclusion criteria included Females aged above 40 years old , patients with endometriosis, abnormal endocrine functions as Diabetes mellitus, thyroid disorders and adrenal abnormalities ,general diseases, those with ovarian cysts or have azospermic partners

Trial design

82 participants in 2 patient groups

pregnant

Description:

women undergoing ICSI who became pregnant

Treatment:

Other: 3 D ultrasound and Doppler examination

Drug: GnRH agonist

Not pregnant

Description:

women undergoing ICSI who fail to achieve pregnancy

Treatment:

Other: 3 D ultrasound and Doppler examination

Drug: GnRH agonist