Endometriosis-Angiopoietin-like Protein-4

Ankara City Hospital

Status: Completed

Conditions: Angiopoietin-like Protein-4; Pelvic Pain; Endometriosis

Treatments: Other: Angiopoietin-like protein-4 (ANGPTL4) Serum Level; Other: Cancer Antigen 125 (CA-125) Serum Level; Other: Angiopoietin-like protein-4 (ANGPTL4) Peritoneal Fluid Level

Study type: Observational

Funder types: Other

Identifiers

NCT07164196

TABED 1-25-1372

Details and patient eligibility

About

Endometriosis is a chronic inflammatory disease associated with pelvic pain, dyspareunia, and impaired ovarian reserve. Cancer antigen-125 (CA-125) is widely studied but limited by low specificity, while angiopoietin-like protein-4 (ANGPTL4) has emerged as a potential biomarker due to its role in angiogenesis and inflammation. In the current study it was aimed to investigate serum and peritoneal fluid ANGPTL4 levels in women with endometriosis compared to healthy controls, and to evaluate their associations with clinical symptoms, serum CA-125, and anti-Müllerian hormone levels.

Enrollment: 80 patients

Sex: Female

Ages: 18 to 44 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of endometriosis for study group who underwent laparoscopic endometriosis surgery
• Healthy women for control group

Exclusion criteria

• Cardiovascular diseases including hypertension
• Type 1 or type 2 diabetes mellitus
• Morbid obesity
• Primary adrenal insufficiency
• Uterine fibroids
• Thyroid dysfunctions including Hashimoto thyroiditis and Grave's disease
• Hepatic dysfunctions
• Renal insufficiency
• Genetic disorders in chromosome constitution or karyotype analysis including monosomy X, trisomy X and gene mutations as BMP15, FMR I, POFIB, and GDF9
• Neurologic diseases
• Psychiatric disorders
• Autoimmune diseases or syndromes including Addison's disease, autoimmune syndromes, scleroderma, Sjogren's syndrome, myasthenia gravis, inflammatory bowel diseases, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and familial Mediterranean fever
• History of any malignancy
• History of exposure to chemotherapeutic agents or radiotherapy

Trial design

80 participants in 2 patient groups

Endometriosis group (Study group)

Description:

The study group included women with endometriosis. The study group consisted of women diagnosed with endometriosis who consecutively underwent laparoscopic endometriosis surgery.

Treatment:

Other: Angiopoietin-like protein-4 (ANGPTL4) Peritoneal Fluid Level

Other: Cancer Antigen 125 (CA-125) Serum Level

Other: Angiopoietin-like protein-4 (ANGPTL4) Serum Level

Healthy women (Control group)

Description:

Control group consisted of healthy women. The control group consisted of women who consecutively visited the outpatient clinic for routine gynecologic examinations and had no known diseases.

Treatment:

Other: Cancer Antigen 125 (CA-125) Serum Level

Other: Angiopoietin-like protein-4 (ANGPTL4) Serum Level