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Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result.
The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.
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Heritability of bipolar disorder is now well established, but seems to be multifactorial in most of the cases.
The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.
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Clinical part :
Genetic part :
29 participants in 1 patient group
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John Rendu, Doctor; Jérôme Holtzmann, Doctor
Data sourced from clinicaltrials.gov
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