Endoscopic Assessment and Prediction of Microbiome-modifying Interventions (microbiome)

Tel Aviv Sourasky Medical Center

Status: Unknown

Conditions: Antibiotic Side Effect; Gut Microbiome

Treatments: Biological: Bacteriotherapy; Dietary Supplement: Probiotic treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT03218579

TASMC-12-ZH-658-CTIL

Details and patient eligibility

About

The investigators would like to examine the extent of gut microbiome rehabilitation in healthy people after the consumption of antibiotics.

Outcomes of probiotic treatment versus bacteriotherapy will be compared.

Full description

The investigators would like to examine the extent of rehabilitation of the composition and functioning of the intestinal bacteria in healthy people after the consumption of antibiotics.

Since the digestive mocus enables the connection between the host and the bacteria that live within it, the investigators would like to characterize the microbiome in the different areas along the digestive system - before antibiotic treatment and after rehabilitation by probiotic treatment versus bacteriotherapy.

Enrollment: 45 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Age: 18 years and up
• Gender: women and men

Exclusion criteria

• Pregnancy
• Age under 18 years
• antibiotic treatment 3 months prior to enrollment
• Viral Hepatitis
• HIV positive

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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45 participants in 3 patient groups

No intervention

No Intervention group

Description:

No intervention after antibiotic treatment.

Probiotic microbiome rehabilitation

Active Comparator group

Description:

Probiotic treatment after antibiotic treatment.

Treatment:

Dietary Supplement: Probiotic treatment

Bacteriotherapy microbiome rehabilitation

Active Comparator group

Description:

Bacteriotherapy after antibiotic treatment.

Treatment:

Biological: Bacteriotherapy