Endoscopic Grading of Intestinal Metaplasia

Soon Chun Hyang University

Status: Completed

Conditions: Magnifying Endoscopy; Gastric Intestinal Metaplasia; Narrow-band Imaging

Treatments: Procedure: Narrow-band imaging endoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT05345314

SCH-EGD-2022

Details and patient eligibility

About

Long-term Helicobacter pylori infection causes premalignant gastric conditions, such as atrophic gastritis and intestinal metaplasia. Image-enhanced endoscopy techniques such as narrow-band imaging (NBI) and magnifying endoscopy improve the diagnosis of gastric intestinal metaplasia (GIM). However, there are no comparative data on the utility of NBI and magnifying endoscopy for diagnosing GIM.

Full description

This study aims to evaluate the diagnostic performance of NBI and magnifying endoscopy for GIM in a country with high risk of gastric premalignant lesions.

Enrollment: 242 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Gastroscopy can be performed
• Pathological analysis can be performed for analysis of gastric atrophy and intestinal metaplasia

Exclusion criteria

• Age < 20 or > 80 years
• Anemia (serum hemoglobin level < 10 g/dL)
• Severe systemic disease
• Advanced chronic liver disease
• Use of certain medications, including proton pump inhibitors, H2-receptor antagonists, or antibiotics
• History of H. pylori eradication
• History of gastric surgery
• Recent history of upper gastrointestinal bleeding