Endoscopic Radiofrequency Ablation of Celiac Ganglion for Pain Management and Improvement of Quality of Life in Patients With Unresectable Pancreatic Cancer

West Virginia University

Status

Enrolling

Conditions

Pancreatic Cancer

Treatments

Procedure: Ablation of Celiac Ganglion

Study type

Observational

Funder types

Other

Identifiers

NCT05535894

2202520088

Details and patient eligibility

About

This study aims to evaluate the EUS-RFA in terms of efficacy for pain management and improvement in quality-of-life parameters for patients with advanced inoperable pancreatic cancer. The primary objectives of this study are to 1) evaluate the utility of EUS-RFA for pain control and improvement in quality-of-life parameters for patients with advanced pancreatic cancer; 2) to measure the reduction of analgesic medications' requirements in patients affected by inoperable pancreatic cancer.

Enrollment

12 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of pancreatic cancer based on clinical, radiological, or pathological assessment;
Referred for abdominal and/or back pain due to pancreatic cancer;
No prior history of RFA;
Cancer pain unresponsive to the WHO 3-step analgesic ladder;
Willingness to consent to participate in the study.

Exclusion criteria

Patients who are not willing to give informed consent or agree to participate in the study
Surgically resectable pancreatic cancer;
Abdominal pain with etiology other than pancreatic malignancy;
Evidence of concurrent infection;
Patients with irreversible coagulopathy international normalized ratio >1.5 or platelet count <50,000/mm3),
Patients with a preliminary diagnosis of adenocarcinoma are not possible established with intraprocedural at EUS-guided FNA.