Endoscopic Submucosal Dissection Versus Esophagectomy for Early Esophageal Carcinoma

Naval Military Medical University

Status: Completed

Conditions: Esophageal Cancer

Treatments: Procedure: Endoscopic submucosal dissection; Procedure: Esophagectomy

Study type: Observational

Funder types: Other

Identifiers

NCT06060106

early esophageal carcinoma

Details and patient eligibility

About

Endoscopic submucosal dissection (ESD) is a minimally invasive alternative to esophagectomy for early esophageal squamous cell carcinoma (EESCC), The data of EESCC patients who received ESD or esophagectomy were retrospectively analyzed,The aim of this study was to compare the efficacy and safety of ESD and esophagectomy in EESCC,Risk factors affecting the prognosis of patients with early esophageal squamous cell carcinoma were analyzed.

Full description

Endoscopic submucosal dissection (ESD) is a minimally invasive alternative to esophagectomy for early esophageal squamous cell carcinoma (EESCC).The aim of this study was to compare the efficacy and safety of ESD and esophagectomy in EESCC，The data of EESCC patients who received ESD or esophagectomy were retrospectively analyzed. Overall survival (OS), disease specific survival (DSS), recurrence free survival (RFS), and procedure-related variables were compared between ESD and esophagectomy patients.Risk factors affecting the prognosis of patients with early esophageal squamous cell carcinoma were analyzed.

Enrollment: 191 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Mucosal or submucosal squamous cell carcinoma of the esophagus
2. no lymph node involvement or distant metastasis on computed tomography (CT) or pathology;

Exclusion criteria

1. Tis premalignant lesions (high-grade intraepithelial neoplasia;HGIN)
2. patients with neoadjuvant therapy
3. patients combined with severe diseases of other organs

Trial design

191 participants in 2 patient groups

Endoscopic submucosal dissection

Description:

Early esophageal cancer patients treated with ESD

Treatment:

Procedure: Endoscopic submucosal dissection

Esophagectomy

Description:

Early esophageal cancer patients treated with esophagectomy

Treatment:

Procedure: Esophagectomy