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Endoscopic Submucosal Resection Turbinoplasty VS Turbinectomy

A

Ahmed Nabil Selim

Status

Completed

Conditions

Turbinate; Hypertrophy Mucous Membrane

Treatments

Procedure: Submucosal Resection Turbinoplasty Versus Partial Inferior Turbinectomy

Study type

Interventional

Funder types

Other

Identifiers

NCT06310083
SMR for Turbinate Hypertrophy

Details and patient eligibility

About

The aim of our study is to compare endoscopic submucosal resection Turbinoplasty and partial inferior turbinectomy regarding clinical and radiological evaluation and its possible complications in the treatment of Chronic inferior turbinate hypertrophy.

Full description

The inferior turbinate (IT) plays a vital function in nose physiology by regulating the temperature and humidity of inhaled air and filtering foreign particles through the mucociliary clearance system.

One of the most common manifestations of chronic rhinitis is nasal obstruction. Nasal obstruction occurs as a result of submucosal or mucosal hypertrophy associated with increased vascularity of the inferior turbinate.

The location, size, and vasoactive capabilities of the inferior turbinate relegate it as a key player in airway resistance. Multiple pathologic processes may alter the gross and microscopic structure of the inferior turbinates, including septal deviation and inflammatory disorders such as allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis. These disorders in turn lead to histological differences in terms of hypertrophy and hyperplasia, distorted cilia, inflammatory cell infiltrates, and mucosal thickening with subsequent macroscopic changes and symptomatic obstruction.

Surgical reduction of the inferior turbinate is warranted to relieve the nasal block caused by the hypertrophied inferior turbinates. Surgical reduction of the inferior turbinate involves removal of the mucosa, soft erectile tissue, and turbinate bone. Different techniques have been applied to increase the nasal airway passage, such as conventional turbinectomy, laser turbinectomy, cryoturbinectomy, electrocautery turbinectomy, conventional Turbinoplasty, microdebrider Turbinoplasty, coblation Turbinoplasty, radiofrequency Turbinoplasty, and ultrasound Turbinoplasty. Conventional turbinectomy (total or partial) is considered very effective in relieving nasal block. Due to the excessive loss of tissue (bone and mucosa), the postoperative complications include excessive bleeding requiring blood transfusion, crusting, pain, and prolonged recovery period. Hence, a more mucosal-friendly approach is preferred; the Turbinoplasty procedure, which resects either soft tissue or bone or both with preservation of the mucosa.

Conventional Turbinoplasty is designed to remove the nonfunctional obstructive part of the turbinate while preserving the functional medial mucosa, which plays the key role in the warming and humidification of air through the nasal passages. Performed endoscopically, inferior Turbinoplasty has the advantage over the other turbinate procedures by preserving sufficient mucosa, while removing adequate obstructed tissue to improve the airway significantly. The other term used for this technique is "submucosal resection", as a reference to its submucosal dissection procedure.

Enrollment

40 patients

Sex

All

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All patients aged between 18 and 45 years complaining with a minimum 3-month duration of nasal obstruction combined with clinical findings of inferior turbinate hypertrophy

Exclusion criteria

  1. Patient's Hemoglobin levels are less than 10gm%.
  2. Patients who were Presented with acute upper respiratory tract infection.
  3. Patients with other causes of nasal obstruction, e.g.,- allergic nasal polyposis, deviated nasal septum.
  4. Patients who have nasal tumors.
  5. Patients who had nasal operations before
  6. Presence of bleeding disorder.
  7. Presence of uncontrolled systemic disease.
  8. During the period of menses

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

40 participants in 2 patient groups, including a placebo group

Submucosal Rescetion Turbinoplasty
Active Comparator group
Description:
participants in this group were applied for Endoscopic submucosal resection Turbinoplasty
Treatment:
Procedure: Submucosal Resection Turbinoplasty Versus Partial Inferior Turbinectomy
Partial Inferior Turbinectomy
Placebo Comparator group
Description:
participants in this group were applied for Partial Inferior Turbinectomy
Treatment:
Procedure: Submucosal Resection Turbinoplasty Versus Partial Inferior Turbinectomy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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