Endoscopic Ultrasound Findings in Esophageal Atresia Following Surgical Repair
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About
Children with esophageal atresia who undergo surgical repair are at risk for anastomotic stricture following surgery. Esophageal stricture can be treated with serial endoscopic dilation but may ultimately need surgical resection if the stricture proves refractory to therapy. Several risk factors have been reported for development of recalcitrant stricture, but to date, no studies have specifically examined the relationship between anastomotic thickness and echotexture at time of initial postoperative endoscopy and treatment outcomes. Other risk factors that have been implicated in the development of recalcitrant stricture include gastroesophageal reflux disease, anastomotic leak, long-gap esophageal atresia, and gestational age. Moreover, it is poorly understood how esophageal layers alter and progress with repeated therapeutic dilation. The investigator hypothesize that the initial thickness and echotexture will help determine therapeutic outcome. It will also help us understand the progression of esophageal echotexture following therapeutic dilation.
Enrollment
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Inclusion criteria
- Patients ages 0-21 years old at time of evaluation with a suspected diagnosis of esophageal stricture secondary to esophageal atresia (with or without Tracheoesophageal fistula) post surgical repair
Exclusion criteria
- Patients with pre-diagnosis of eosinophilic esophagitis
- Patients with pre-diagnosis of congenital esophageal stricture
- Patients diagnosed with esophageal stricture secondary to caustic ingestion
- Patient is diagnosed with an esophageal perforation at time of endoscopy
Trial design
Primary purpose
Allocation
Interventional model
Masking
50 participants in 1 patient group
Trial contacts and locations
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Central trial contact
osama baghdadi, MBBS
Data sourced from clinicaltrials.gov
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