Endostar Combine With Radiotherapy in Brain Metastasis of NSCLC

Huazhong University of Science and Technology

Status and phase: Unknown; Phase 2

Conditions: Non-small Cell Lung Cancer

Treatments: Drug: endostar; Radiation: radiotherapy; Drug: Placebos

Study type: Interventional

Funder types: Other

Identifiers

NCT03614065

endobrain

Details and patient eligibility

About

Observe the effect os radiotherapy plus or not plus endostar in the treatment of brain metastasis in NSCLC

Full description

The investigators will observe the time controlled by the brain lesion after the test and the total survival time of the patients. Meanwhile, during each follow-up, the investigators will extract cerebrospinal fluid for genomic analysis of cerebrospinal fluid

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• NSCLC Brain metastasis

Exclusion criteria

• KPS<60

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

50 participants in 2 patient groups, including a placebo group

arm a

Placebo Comparator group

Description:

This group is a placebo control group, and we will use radiation therapy plus Placebos as the control group for the study

Treatment:

Drug: Placebos

Radiation: radiotherapy

arm b

Experimental group

Description:

This group belongs to the experimental group. We will use radiotherapy combined with endostar for treatment, so as to judge the efficacy of the medicine

Treatment:

Radiation: radiotherapy

Drug: endostar