Endothelial Cell Gene Networks of CVD

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Tufts University

Status

Withdrawn

Conditions

Coronary Heart Disease

Treatments

Other: isolation of endothelial cells precursors in blood

Study type

Observational

Funder types

Other

Identifiers

NCT03529916
12841

Details and patient eligibility

About

The objective of this study is to identify relevant signature gene networks of cardiovascular disease in endothelial cells derived from circulating endothelial progenitor cells of individuals with established cardiovascular disease (CVD).

Full description

The investigators propose to enroll CVD and healthy subjects between 30 and 60 years of age, matched for age, gender, body mass index, and medication (statin and anti-hypertensive) use. Circulating endothelial progenitor cells will be isolated from blood and cultured in vitro to differentiate into endothelial cells.

Sex

All

Ages

30 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for CVD subjects::

• >50% stenosis of one or more coronary arteries

Inclusion Criteria for Healthy subjects:

• absence of coronary artery stenosis

Exclusion Criteria for all subjects:

  • type 2 diabetes mellitus
  • chronic kidney disease,
  • other chronic diseases
  • dyslipidemia (fasting plasma LDL-C >160 mg/dL and triglyceride levels >150 mg/dL)

Trial design

0 participants in 2 patient groups

CVD subjects
Description:
CVD will be defined as >50% stenosis of one or more coronary arteries as assessed by coronary angiography.
Treatment:
Other: isolation of endothelial cells precursors in blood
healthy controls
Description:
healthy controls defined as not having stenosis of coronary arteries as assessed by coronary angiography.
Treatment:
Other: isolation of endothelial cells precursors in blood

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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