Endothelial Cell Specific Molecule-1 (ESM-1): a Novel Biomarker for ARDS Endothelial Injury

Jingyuan,Xu

Status: Unknown

Conditions: Evaluate the Correlation Between the Level of ESM-1 and the Prognosis of the Patients With ARDS

Study type: Observational

Funder types: Other

Identifiers

NCT03296761

2017ZDSYLL081-P01

Details and patient eligibility

About

To observe the changes of plasma ESM-1 levels in patients with ARDS, and to explore its clinical significance.

Full description

70 patients who diagnosed as ARDS were included in this study. Then keep blood samples from these patients in the first day, the third day and the seventh day, detect ESM-1 level in plasma by ELISA. Record Severity of illness and survival status of every patient within 28 days. Objective to evaluate the correlation between the level of ESM-1 in plasma and the prognosis of the patients.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Patients admitted to ICU diagnosed of ARDS (Berlin definition）in 48h
2. Patients age between 18 years old and 80 years.

Exclusion Criteria：

1. Pregnant women,
2. Patients with malignant tumor,
3. Immunosuppression or immunocompromised patients.

Trial design

70 participants in 2 patient groups

ESM-1<5ng/ml

ESM-1≥5ng/ml