Endothelial Changes in Diabetic and Non-diabetic Patients Undergoing Phacoemulsification

Al-Azhar University

Status: Completed

Conditions: Endothelial Cell Density Loss

Treatments: Procedure: Phacoemulsification

Study type: Interventional

Funder types: Other

Identifiers

NCT07369388

Endothelial Changes

Details and patient eligibility

About

The aim of this study is to evaluate and compare specular endothelial changes in diabetic and non-diabetic patients undergoing phacoemulsification by assessing endothelial cell density, coefficient of variation, and percentage of hexagonal cells preoperatively and postoperatively. This study also seeks to provide updated evidence on the influence of diabetes on corneal endothelial response to cataract surgery and to support evidence-based strategies for optimizing surgical outcomes

Enrollment: 100 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 40 years
• Presence of senile cataract suitable for phacoemulsification
• Clear cornea with no clinical signs of endothelial decompensation
• Ability to undergo specular microscopy examination
• For the diabetic group: confirmed diagnosis of type 2 diabetes mellitus

Exclusion criteria

• History of previous ocular surgery or trauma
• Corneal pathology affecting the endothelium
• Glaucoma or history of raised intraocular pressure
• Pseudoexfoliation syndrome
• Intraoperative complications

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Diabetic group

Active Comparator group

Treatment:

Procedure: Phacoemulsification

Non-Diabetic group

Active Comparator group

Treatment:

Procedure: Phacoemulsification