Endothelial Dysfunction and Chronic Obstructive Pulmonary Disease

Andrea Vukic Dugac

Status: Completed

Conditions: Endothelial Dysfunction; Chronic Obstructive Pulmonary Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02092675

ED-1971-HR

ED-1971-UHCZ (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to investigate the role of endothelial dysfunction in chronic obstructive pulmonary disease.

Full description

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in developed countries. Acute exacerbations and cardiovascular diseases are the major causes of morbidity and mortality in COPD patients. According to the frequency of exacerbations, phenotype "frequent exacerbator" is defined and characterised with severe clinical course and was recognised as an increased risk for cardiovascular mortality. Recent studies considered that systemic inflammation plays a key role in the pathogenesis of COPD and endothelial dysfunction is a suspected link between increased cardiovascular mortality and systemic inflammation in COPD patients. Endothelial dysfunction is assessed by determining flow mediated dilatation index (FMD index) or plasma markers. Previous studies have suggested the presence of endothelial dysfunction in COPD patients, as well as the deterioration of endothelial function during exacerbations of COPD. This study will, for the first time, systematically explore endothelial dysfunction in two phenotypically distinct groups of COPD patients with simultaneous assessment of endothelial function flow mediated dilatation index (FMD index) and plasma markers.

Enrollment: 117 patients

Sex: All

Ages: 40 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• COPD patients in stable condition ( without exacerbation min 1 months ago)
• Over 40 years
• History of at least 10 py

Exclusion criteria

• acute exacerbation of COPD
• active malignancy
• autoimmune disease
• acute myocardial infarction
• diabetes mellitus with late complications
• congestive heart failure
• women of childbearing potential

Trial design

117 participants in 3 patient groups

COPD patients - frequent exacerbator

Description:

COPD patients with 2 and more exacerbation in one year

COPD patients - non frequent exacerbator

Description:

COPD patients with less than 2 exacerbation during one year

control group - healthy smokers

Description:

healthy smokers, they do not have COPD