Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease

Hospital Universitari Son Dureta

Status

Completed

Conditions

Endothelial Dysfunction

Chronic Obstructive Pulmonary Disease

Study type

Observational

Funder types

Other

Identifiers

NCT00831220

PI04/1946

Details and patient eligibility

About

Objective: To investigate the potential role of endothelial dysfunction as a pathogenic mechanism of cardiovascular events in COPD. Hypothesis: endothelial function is abnormal in patients with COPD, particularly during exacerbations of the disease. Design: prospective and controlled study performed in an university hospital. Population: we compare 4 groups of subjects, 44 patients with stable COPD, 35 patients with acute exacerbation of COPD, 10 smokers or former smokers with normal lung function and 10 never smokers matched by physical activity and BMI. Study variables: a) clinical variables: clinical information, physical examination, pulmonary function tests, ECG and sputum culture; b) Biological variables: number of Circulating Endothelial Progenitor Cells, vascular growth factors (vascular endothelial growht factor and erythropoietin), systemic inflammation (C-reactive protein, white blood cells), peripheral venous blood test (including hemogram, biochemical analysis with glycemia, cholesterol, LDLcol, HDLcol); and c) systemic vascular reactivity assessment.

Enrollment

99 patients

Sex

Male

Ages

45+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients with moderate to very severe COPD admitted in the hospital because of an exacerbation, and,
Patients with moderate to very severe COPD in stable condition.

Exclusion criteria

Patients with an exacerbation of COPD who needed invasive or non invasive mechanical ventilation
Patients with other chronic inflammatory diseases.
Patients with other acute or active chronic systemic disease such as heart failure, renal insufficiency, etc.