Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease

Yonsei University

Status and phase: Unknown; Phase 4

Conditions: Coronary Heart Disease

Treatments: Drug: Atorvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT00917527

20090615

Details and patient eligibility

About

The aim of this prospective study is to investigate the prevalence of endothelial dysfunction in subjects with family history of premature coronary heart disease. At the same time, the effect of atorvastatin in treating subclinical endothelial dysfunction in those patients will be evaluated.

Enrollment: 77 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• within 1 year
• the siblings of premature coronary heart disease(male<55years old, female<65years old: Framingham Heart Study)patients admitted relevant hospital

Exclusion criteria

• Documented coronary heart disease
• Any woman of childbearing potential who is pregnant, seeking to become pregnant or suspects that she may be pregnant.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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77 participants in 2 patient groups, including a placebo group

Control

Placebo Comparator group

Treatment:

Drug: Atorvastatin

Atorvastatin

Experimental group

Treatment:

Drug: Atorvastatin