Endothelial Dysfunction Induced by Postprandial Lipemia

Norwegian University of Science and Technology

Status and phase: Completed; Phase 2

Conditions: Healthy Subjects

Treatments: Other: exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT00660491

Exercise, Food and Endothelium

Details and patient eligibility

About

Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.

Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).

Enrollment: 8 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male, 20-40years, BMI between 25 and 30, resident in Trondheim.

Exclusion criteria

• unstable angina, CHD, heart failure,

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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8 participants in 3 patient groups

1

No Intervention group

Description:

Control

2

No Intervention group

Description:

moderate exercise training group

3

Experimental group

Description:

high intensity exercise group

Treatment:

Other: exercise training