Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil

Baruch Padeh Medical Center

Status and phase: Withdrawn; Phase 4

Conditions: Sickle Cell Anemia

Treatments: Drug: placebo; Drug: Viagra (Sildenafil)

Study type: Interventional

Funder types: Other

Identifiers

NCT00937144

SCA123-CTIL

Details and patient eligibility

About

The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with sickle cell anemia

Exclusion criteria

• patients with sickle cell anemia during acute crisis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

15 participants in 2 patient groups, including a placebo group

viagra

Experimental group

Description:

viagra versus placebo will be given to patients with sickle cell anemia

Treatment:

Drug: Viagra (Sildenafil)

placebo

Placebo Comparator group

Description:

viagra versus placebo will be given to patients with sickle cell anemia

Treatment:

Drug: placebo