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Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes

Joslin Diabetes Center logo

Joslin Diabetes Center

Status

Completed

Conditions

Insulin Resistance
Obesity

Study type

Observational

Funder types

Other

Identifiers

NCT01926938
CHS#: 03-30

Details and patient eligibility

About

Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with diabetes. Endothelial function and vascular reactivity are impaired not only in white adults with type 2 diabetes but also in those at risk for the disease by virtue of having impaired glucose tolerance or parental history of type 2 diabetes. Whether this finding is applicable to hispanics is not known. The investigators plan to assess the endothelial function and vascular reactivity in young Hispanic adults at risk of developing type 2 diabetes by virtue of being obese and belonging to a minority population.

Enrollment

44 patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Group 1:

    1. Age between 18-40 years;
    2. Hispanic (we will consider a subject being Hispanic if both parents are reported as Hispanics when asked the following question: "What ethnic group do you consider that you belong to?");
    3. History of type 2 diabetes in one or both parents;
    4. BMI above 27;
    5. Not have participated in any exercise program for the 6 months prior to the beginning of the study.

Group 2:

  1. Age between 18-40 years;
  2. Hispanic (same criteria as above );
  3. No history of type 2 diabetes in any first degree relative;
  4. BMI under 25;
  5. Not have participated in any exercise program for the 6 months prior to the beginning of the study.

Exclusion criteria

  • diabetes, glucose intolerance, pregnancy, smoking, cardiovascular disease, uncontrolled hypertension, renal disease, proteinuria, cancer, infectious diseases, severe GI diseases, lung disease, electrolyte abnormalities, anemia, endocrine disorders, severe dyslipidemia, peripheral vascular disease, medications: beta-blockers, any diuretic, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, niacin, glucocorticoids, any antineoplastic agent, antibiotics, psychoactive agents, bronchodilators or insulin.

Trial design

44 participants in 2 patient groups

adults at risk
Description:
Latino adults with family history of type 2 diabetes
controls
Description:
Latino adults without family history of type 2 diabetes and normal glucose tolerance

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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