Endothelial Glycocalyx Damage in Brain Death Organ Donors

University Hospital Hradec Kralove

Status: Active, not recruiting

Conditions: Organ Transplant Failure or Rejection; Organ Donors; Brain Damage Due to Hypoxia

Treatments: Diagnostic Test: Endothelial glycocalyx damage assessment

Study type: Observational

Funder types: Other

Identifiers

NCT05609123

CooperatioUK_DBD_GCX

Details and patient eligibility

About

The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients in critical condition declared as brain dead by clinical examination

Exclusion criteria

• N/A

Trial design

100 participants in 1 patient group

Brain dead organ donors

Description:

Patients with clinically proven bain death were assigned to the paraclinical confirmatory investigation of the brain death and subsequently accepted into the transplantation program.

Treatment:

Diagnostic Test: Endothelial glycocalyx damage assessment