Endotoxins and Cytokines Removal During Continuous Hemofiltration With oXiris™ (ECRO)

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Civil Hospices of Lyon

Status

Completed

Conditions

Peritonitis
Septic Shock

Treatments

Device: CVVH using PrismafleX HF1400 filter
Biological: Ultrafiltrate sampling
Biological: Arterial blood sampling
Device: CVVH using oXiris™ filter

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT03426943
69HCL17_0014
2017-A03366-47 (Other Identifier)

Details and patient eligibility

About

Sepsis is a major cause of death in Intensive Care Units and therefore finding new therapies to improve survival rates and limit morbidity is a major goal. Over the past decades, blood purification has been proposed as an adjuvant therapy for sepsis. The goal of blood purification is to restore the immune homeostasis and efficiency through the removal of bacterial products including endotoxins, broad-spectrum cytokines and other inflammatory mediators. Indeed, the large and overwhelmed release of these mediators in the early phase of sepsis may induce multiple organ failure syndrome. In 2017, different techniques are proposed for blood purification. Among them, the highly adsorptive membrane, oXiris™, seems promising. This membrane can be used in case of Acute Kidney Injury associated with sepsis and exhibits enhanced blood purification capacities. Previous studies on animals have already proven that this membrane can remove broad-spectrum cytokines but also endotoxins from the blood. This ability to remove endotoxins is particularly interesting since endotoxins are believed to be the trigger of the immune cascade at the initiation of sepsis. The lack of clinical evidence is the main limit to a wider use of this membrane. Therefore, the aim of the present clinical trial is to characterize the blood purification properties of the membrane in a human clinical setting. The oXiris™ membrane is specifically designed to improve the adsorptive capacities of the polyacrylonitrile-based AN69 membrane. Its extremely rich coating of polyethyleneimine (PEI) gives the membrane the ability to bind and remove not only cytokines but also endotoxins due to the positive charges of PEI at the surface of the membrane. The tested hypothesis is that the oXiris™ filter allows for a greater endotoxin and cytokine removal compared to a standard polysulfone ("PrismafleX HF1400") filter in patients with septic shock.

Enrollment

39 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Male or female aged ≥ 18 years old,
  • "Early" septic shock (in the first 12 hours after Intensive Care Unit (ICU) admission or readmission in the ICU after surgery), with lactatemia > 2 mmol/L and norepinephrine needs > 0.2 µg/kg/min 2 hours after the end of the initial surgery (to ensure that a potential anesthesia effect as disappeared),
  • Secondary to a community-acquired or a nosocomial peritonitis (secondary or tertiary but not primary peritonitis),
  • AKI KDIGO ≥ stage 2 or another indication for renal replacement therapy, according to the clinician in charge (if baseline creatinine is unknown, KDIGO ≥ stage 2 can be defined by a serum creatinine ≥ 2-fold the normal creatinine for age, gender, and ethnicity).

Exclusion criteria

  • Inability to obtain informed consent from the patient or next of kin,
  • Actual participation in another interventional study,
  • Contraindications to citrate,
  • Allergy to heparin,
  • Pregnant or breastfeeding woman,
  • Neutropenia < 0.5 G/L resulting from chemotherapy or other iatrogenic causes
  • Patient receiving immunosuppressive therapy, long-term corticosteroids, therapeutic antibodies, chemotherapy in the last 6 months (whatever the dose),
  • Patient with innate or acquired immune deficiency (for example severe combined immunodeficiency, HIV or AIDS)
  • Onco-hematological disease (lymphoma, leukemia, myeloma) treated within the last 5 years (but inclusion of a patient with solid cancer who did not receive chemotherapy during the past 6 months is possible),
  • Patient with expected ICU length of stay < 48 hours,
  • Patient for whom a limitation of active care was pronounced at the time of enrollment,
  • Patient with no social security insurance, with restricted liberty, or under legal protection.

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

39 participants in 2 patient groups

CVVH using oXiris™ filter
Experimental group
Description:
Patients included in this arm will have renal replacement therapy by performing Continuous Veno-Venous Hemofiltration (CVVH) using oXiris™ membrane. They will also have arterial blood sampling and ultrafiltrate sampling during the CVVH.
Treatment:
Device: CVVH using oXiris™ filter
Biological: Ultrafiltrate sampling
Biological: Arterial blood sampling
CVVH using PrismafleX HF1400 filter
Active Comparator group
Description:
Patients included in this arm will have renal replacement therapy by performing CVVH using a standard polysulfone filter (PrismafleX HF1400). They will also have arterial blood sampling and ultrafiltrate sampling during the CVVH.
Treatment:
Biological: Ultrafiltrate sampling
Biological: Arterial blood sampling
Device: CVVH using PrismafleX HF1400 filter

Trial contacts and locations

8

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Central trial contact

Valérie CERRO, CRA; Thomas RIMMELE, MD, PhD

Data sourced from clinicaltrials.gov

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