Endotracheal Suctionning During Positive Pressure Extubation in ICU (INTENTION)

Centre Hospitalier Régional d'Orléans

Status: Not yet enrolling

Conditions: Weaning Invasive Mechanical Ventilation; Rox Index; Oxygen Saturation Measurement; Mechanical Ventilation With Oral Intubation; Extubation

Treatments: Procedure: Suctionning extubation; Procedure: No suctionning Extubation

Study type: Interventional

Funder types: Other

Identifiers

NCT07130123

CHUO-2025-12

Details and patient eligibility

About

The aim of this clinical trial is to evaluate endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients (over 18 years old) in the intensive care unit (ICU). The main question it aims to answer is whether the intervention improves the respiratory oxygenation index (ROX) three hours after extubation compared to no endotracheal suction during positive pressure extubation.

Participants will only need to be extubated by the nursing team in the ICU. Follow-up will consist of evaluating respiratory rate, pulse oximetry and inspired oxygen fraction for three hours following extubation.

Full description

This is a prospective, randomised, controlled trial. The aim of this study is to evaluate endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients (over 18 years old) in the intensive care unit (ICU). The main question it aims to answer is whether the intervention improves the respiratory oxygenation index (ROX) three hours after extubation compared to no endotracheal suction during positive pressure extubation.

Inclusion : Participants who meet eligibility criteria will be randomized into experimental arm (endotracheal suctioning during positive pressure extubation) or control arm (no endotracheal suction during positive pressure extubation).

Intervention and Follow-up : participants will only need to be extubated by the nursing team in the ICU. Follow-up will consist of evaluating respiratory rate, pulse oximetry and inspired oxygen fraction for three hours following extubation.

End of study : at the end of the study visit (28 days after extubation), vital status of participants will be recorded.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient
• Intubated for more than 48 hours
• Patient for whom extubation is prescribed by the patient's physician

Exclusion criteria

• Headboard restriction>30°.
• Decision to limit active treatment in advance of reintubation
• Protected person (under guardianship or curatorship)
• Person under court protection
• Persons deprived of liberty
• Persons not affiliated to a social security scheme
• Pregnant or breast-feeding woman
• No co-inclusion with a study whose period of interest is follow-up within 3 hours of extubation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 2 patient groups

Suctionning Extubation (experimental arm)

Experimental group

Description:

Endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients in the intensive care unit.

Treatment:

Procedure: Suctionning extubation

No Suctionning Extubation (control arm)

Sham Comparator group

Description:

No endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients in the intensive care unit.

Treatment:

Procedure: No suctionning Extubation