Endotypic Stability in CRS

Thomas Jefferson University

Status: Enrolling

Conditions: Chronic Sinusitis

Treatments: Other: no intervention

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT06272123

20D.776

Details and patient eligibility

About

A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients with Chronic sinusitis (with or without polyps)
• Undergoing endoscopic sinus surgery during the study period
• More than 18 years
• No chronic illness/ malignancy

Trial design

200 participants in 2 patient groups

Chronic Sinusitis

Treatment:

Other: no intervention

Controls

Treatment:

Other: no intervention