Endovascular Graft Anchoring Different Regions of Ascending Aorta in the Treatment of Ascending Aortic Dissection

Chinese Medical Association

Status

Unknown

Conditions

Ascending Aortic Dissection

Treatments

Device: Stent grafts anchored in different areas

Study type

Observational

Funder types

Other

NETWORK

Identifiers

NCT04544579

https://orcid.org/0000-0002-07

Details and patient eligibility

About

Aortic dissection is a deadly and dangerous disease. About 28% of patients with ascending aortic dissection can't tolerate open surgical trauma caused by thoracotomy and cardiopulmonary bypass, and the prognosis is poor. Minimally invasive endovascular treatment has been applied in the treatment of descending aortic dissection. However, due to the special anatomical structure and high speed /pressure blood flow, the treatment of ascending aorta dissection has become an international difficulty.

Full description

This study was designed combination of retrospective and prospective methods, and focused on distal false lumen Aneurysmal Expansion of Aortic Dissection (DAEAD) . To formulate clinical data for the risk assessment of DAEAD, and best intracavitary treatment or long-term efficacy evaluation, we combined the results of genetic testing, evaluating the missense mutation, computer simulation of blood flow dynamics analysis, and clinical imaging analysis.

Enrollment

200 estimated patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aortic dissection diagnosed by CTA;
With indications for endovascular treatment
The luminal graft anchor is required to be located in the ascending aorta.

Exclusion criteria

Import difficult, such as external iliac artery diameter is less than 6 mm bilateral iliac, artery stenosis distortions;
Patients with severe comorbidities, such as severe myocardial insufficient blood supply, heart failure, arrhythmia, severe renal dysfunction, and severe blood coagulation dysfunction;
Patients with malignant tumor, or other serious illness, life expectancy of less than 1 year；
Puncture local infection and high fever;⑤ within 1 month of the large area;
Contrast media in patients with cerebrovascular accident or digestive tract hemorrhage patients with allergies;
Aortic ulcer or aortic wall hematoma and other atypical dissection.