Endovascular Magnesium Sampling in Acute Stroke

University of Southern California

Status: Terminated

Conditions: Acute Stroke

Treatments: Other: endovascular sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT01502748

HS-11-00311

12BGIA8700001 (Other Grant/Funding Number)

Details and patient eligibility

About

This investigation will address the safety and feasibility of distal, intra-arterial sampling through endovascular access, in acute stroke patients. Levels of Magnesium will be measured in the region of infarct in patients who had been treated with intravenous Magnesium therapy following an acute stroke. This study attempts to address whether the traditional intravenous means of neuroprotectant administration achieves adequate concentration of the therapeutic agent in the area of diseased tissue.

Enrollment: 2 patients

Sex: All

Ages: 40 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patient with acute cerebral ischemia due to ICA or MCA occlusion,
2. Patient already enrolled in the NIH FAST-MAG clinical trial,
3. Patient's clinical attending physician plans mechanical embolectomy procedure as part of routine clinical care.
4. Age 40-95 inclusive (age criteria for FAST-MAG Trial).

Exclusion criteria

1. Technical inability to navigate microcatheter to target clot.
2. Patient or surrogate unavailable for consent

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2 participants in 1 patient group

Endovascular Sampling

Experimental group

Description:

Paired sampling from the distal arterial(endovascular catheter) and peripheral venous (femoral sheath) locations in acute stroke patients undergoing endovascular recanalization who received intravenous Magnesium Sulfate as a part of the FAST-MAG study

Treatment:

Other: endovascular sampling