Endurance Training in Patients With Post-TB Lung Disease

Riphah International University

Status: Completed

Conditions: Tuberculosis; Post-Tuberculous Bronchiectasis; Post-Tuberculous Pleural Fibrosis

Treatments: Other: Control; Other: Experimental

Study type: Interventional

Funder types: Other

Identifiers

NCT06047795

Rec/01657 Safa Marwa

Details and patient eligibility

About

To determine the effects of endurance training on functional capacity and QOL(Quality of life) in patients with post-TB (tuberculosis) lung disease. Post-tuberculosis lung disease is a major health concern nowadays. There is limited evidence in the literature regarding the rehabilitation of patients with cured tuberculosis which leads to post-TB complications.

Full description

Adults with post-TB respiratory symptoms experience skeletal muscle weakness due to inactivity, systemic inflammation, and poor nutrition, which is frequently made worse by poverty. Such patients experience a vicious cycle that includes decreased body weight, increasing morbidity, and higher mortality. People with Chronic Respiratory Diseases frequently avoid exercise, which causes them to lose motivation and decondition. This cycle of decline continues. In Pakistan, there is no concept of pulmonary rehabilitation for TB patients. The current study will attempt to fill this literature gap and also promote the concept of pulmonary rehabilitation for post-tuberculosis patients in Pakistan.

Enrollment: 36 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• TB (diagnosed) with Completed TB course
• Dyspnea (with or without cough)
• Age (18-50yrs).
• After 3 months of AFB and gene expert (-)
• Decreased PFT predicted values

Exclusion criteria

• Smoker, Diabetes, and cardiac patients
• Physical disabled, pregnant (lactating women)
• Sputum + testing for TB
• Gene expert
• CVD (unstable)
• Not willing to participate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

36 participants in 2 patient groups, including a placebo group

Interventional

Experimental group

Description:

Aerobic and respiratory endurance exercises with patient education

Treatment:

Other: Experimental

Control

Placebo Comparator group

Description:

Usual care (Patient Education, Home Plan)

Treatment:

Other: Control