Energetic Response to Feeding and Exercise in SCI (CRIT)

University of Miami

Status: Completed

Conditions: Spinal Cord Injuries

Treatments: Other: Liquid Meal; Behavioral: High intensity interval training (HIIT); Behavioral: Seated control (CON); Behavioral: Circuit resistance training (CRT); Behavioral: Moderate intensity continuous (MICT)

Study type: Interventional

Funder types: Other

Identifiers

NCT03545867

20171114

Details and patient eligibility

About

This study investigates the effect of various forms of upper extremity exercise on postprandial glycemia and lipemia in persons with spinal cord injury (SCI). Participants are measured at rest and fed a standardized meal following seated rest (CON), moderate intensity continuous arm cycling (MICT), high intensity interval arm cycling (HIIT), and circuit resistance exercise (CRT) matched for exercise energy expenditure.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult (>/=18 years of age)
• Neurologically stable chronic (>/= 1year) spinal cord injury (SCI)
• American Spinal Injury Association Impairment Scale (AIS) grade A, B, or C
• SCI at level </= the first thoracic vertebrae (T1)

Exclusion criteria

• Being of ≤ 18 years of age.
• Contraindication to exercise (ACSM Guideline, 10th edition)
• Lower extremity fracture or dislocation within 6 months of participation,
• History head injury or seizures.
• Inability to consent.
• Restrictions in upper extremity range of motion that would prevent an individual from achieving an unhindered arm cycling motion or moving throughout a range needed to perform resistance maneuvers.
• A pressure ulcer at ischial/gluteus, trochanteric, sacral, or heel sites within the last 3 months.
• Pregnancy determined by urine testing in sexually active females.
• Imprisonment in state or federal jail or prison.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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10 participants in 4 patient groups

Seated control (CON)

Experimental group

Description:

Participants remain seated in their habitual wheel chair for \~45 min (duration of exercise performed in other arms). Following the intervention they are fed.

Treatment:

Other: Liquid Meal

Behavioral: Seated control (CON)

Circuit resistance training (CRT)

Experimental group

Description:

Participants complete upper extremity resistance maneuvers (lifts) interspersed with low-load/high-speed arm cycling for a combined 30 repetitions of 6 lifts and \~20 min of arm cycling. During this time energy expenditure is measured via open-circuit indirect calorimetry. Following the intervention they are fed.

Treatment:

Other: Liquid Meal

Behavioral: Circuit resistance training (CRT)

Moderate intensity continuous (MICT)

Experimental group

Description:

Participants complete continous arm cycling at a steady-state power output (intensity) matched to the energy expenditure (kcal/min) and duration of exercise (min) response during CRT. Following the intervention they are fed.

Treatment:

Other: Liquid Meal

Behavioral: Moderate intensity continuous (MICT)

High intensity interval training (HIIT)

Experimental group

Description:

Participants complete interval arm cycling at power output that varies between 2 min "active" and two min "recovery" periods. This interval exercise is matched to the total energy expenditure (accumulated kcals) response during CRT. Following the intervention they are fed.

Treatment:

Other: Liquid Meal

Behavioral: High intensity interval training (HIIT)