Energy Drinks and Vascular Function

University of Florida

Status: Completed

Conditions: Vascular Function

Treatments: Other: Control drink; Other: caffeinated drink; Other: Total sleep deprivation; Other: Energy gum; Other: energy drink; Other: placebo gum

Study type: Interventional

Funder types: Other

Identifiers

NCT03324256

IRB201700678

Details and patient eligibility

About

The purpose of this study will be to examine the acute effect of commercially available energy products on endothelial function, arterial stiffness and thrombosis in healthy young males.

Full description

The use of energy products has significantly increased in the last few years and is especially high among young men. The present study will compare the acute effect of a commercially available energy drink, energy gum, coffee and control beverage on endothelial function, arterial stiffness and circulating markers of thrombosis, inflammation and oxidative stress.

Enrollment: 19 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being Male
• 18-30 years of age
• No indication of major clinical disease (e.g. diabetes, hypertension, significant arrhythmias, syncope and cardiovascular disease)
• BMI ≤ 30 kg/m^2 and blood pressure ≤ 140/90 mmHg
• Consumption of <400mg of caffeine/day
• Prior history of consumption of energy drinks

Exclusion criteria

• Being female
• Age <18 or >30 years
• BMI> 30 kg/m^2 and blood pressure > 140/90 mmHg
• Use of medication that may affect vascular measures
• Use of tobacco products including smoking
• Vegan or vegetarian diet
• Being energy drink or caffeine naïve or consumption of >400 mg of caffeine/day
• Consumption of >1 energy drinks per month
• Being a shift worker

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

19 participants in 5 patient groups, including a placebo group

Energy drink and placebo gum

Active Comparator group

Description:

Commercially-available energy drink (16oz) + 2 pieces of placebo gum

Treatment:

Other: energy drink

Other: placebo gum

Caffeinated drink and placebo gum

Active Comparator group

Description:

Commercially-available caffeinated drink (16oz) + 2 pieces of placebo gum

Treatment:

Other: caffeinated drink

Other: placebo gum

Control drink and energy gum

Active Comparator group

Description:

Control drink (16oz) + 2 pieces of energy gum

Treatment:

Other: Control drink

Other: Energy gum

Control drink and placebo gum

Placebo Comparator group

Description:

Control drink (16oz) + 2 pieces of placebo gum

Treatment:

Other: Control drink

Other: placebo gum

Energy drink and total sleep deprivation

Active Comparator group

Description:

Commercially-available energy drink (16oz) + 2 pieces of placebo gum following total sleep deprivation

Treatment:

Other: energy drink

Other: Total sleep deprivation

Other: placebo gum