Energy Expenditure and Substrate Utilization During Acute Under- and Over-feeding

University of North Carolina (UNC) logo

University of North Carolina (UNC)

Status

Completed

Conditions

Obesity

Treatments

Other: 24-hour energy expenditure

Study type

Interventional

Funder types

Other

Identifiers

NCT01740765
12-0681

Details and patient eligibility

About

This study will determine the impact of 24, 48 and 72 hours of over and underfeeding on energy expenditure as measured in the metabolic chamber at the UNC Chapel Hill Nutrition Research Institute (UNC NRI).

Full description

Subjects will complete a baseline eucaloric study day. Following this, subjects will be randomized to complete 3 days of overfeeding (150% of baseline eucaloric energy requirements) or 3 days of underfeeding (50% of baseline eucaloric energy requirements). After completing one of these study arms, subjects will cross-over and complete the second arm. All study arms will be separated by two weeks. 24-hour energy expenditure will be measured 3 times during each of 3 day periods. We hypothesize that the impact of over or underfeeding on EE will be evident after 24-hours and will be comparable to 72 hour EE.

Enrollment

7 patients

Sex

Female

Ages

50 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Woman
  • Postmenopausal
  • Aged 50-65 years
  • BMI 25-35kg/m2
  • Not taking blood pressure or anti-inflammatory medications or any other medications that may impact the results
  • Thyroid hormone profile within the normal reference range
  • No medical condition which may impact the results (e.g. diabetes)
  • Accustomed to eating regular meals including breakfast

Exclusion criteria

  • Smoker
  • Heavy exerciser (defined as >150 minutes/week for more than 3 months)
  • Abuses alcohol or drugs
  • Vegetarian

Trial design

7 participants in 3 patient groups

Eucaloric Feeding
Experimental group
Description:
Subjects will complete an initial eucaloric feeding study day. During this study day, subjects will receive 100% of their calorie requirements. 24-hour energy expenditure will be measured.
Treatment:
Other: 24-hour energy expenditure
Underfeeding
Experimental group
Description:
Following the eucaloric feeding study day, subjects will undergo the underfeeding and overfeeding arms in random order. During the underfeeding study arm, subjects will receive 50% of their calorie requirements (as determined during the initial eucaloric study day) for 3 days. 24-hour energy expenditure will be measured.
Treatment:
Other: 24-hour energy expenditure
Overfeeding
Experimental group
Description:
Following the eucaloric feeding study day, subjects will undergo the underfeeding and overfeeding arms in random order. During the overfeeding study arm, subjects will receive 150% of their calorie requirements (as determined during the initial eucaloric study day) for 3 days. 24-hour energy expenditure will be measured.
Treatment:
Other: 24-hour energy expenditure

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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