Energy Expenditure of People Living With HIV/AIDS

University of Sao Paulo General Hospital

Status: Completed

Conditions: HIV Lipodystrophy Syndrome; HIV/AIDS

Treatments: Drug: use of lipid-lowering drugs.

Study type: Observational

Funder types: Other

Identifiers

NCT02530827

CAAE 01848612.1.0000.5440

Details and patient eligibility

About

Background: Several studies have reported increased resting energy expenditure (REE) in people living with HIV/AIDS possibly due to changes in body composition that occurs in HIV lipodystrophy syndrome.

The aim of this study was to evaluate the influence of the use of lipid-lowering drugs in resting energy expenditure (REE) and total energy expenditure (TEE) in patients seropositive for HIV in treatment of lipodystrophy.

Full description

REE was measured by indirect calorimetry.

TEE was measured by doubly labeled water (DLW) technique and an activity monitor based on accelerometry (AM).

Enrollment: 45 patients

Sex: Male

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Use of antiretroviral therapy for at least 4 months
• A cluster of differentiation 4 (CD4) T-cell count of >200 cells/mm3
• Use of lipid-lowering drugs for at least 1 month (group HIV-seropositive with lipodystrophy and use of lipid-lowering)

Exclusion criteria

• Signs or symptoms of opportunistic infections
• Thyroid disease

Trial design

45 participants in 3 patient groups

LIPO-HIPO-

Description:

HIV-seropositive without lipodystrophy and no use of lipid-lowering drugs.

LIPO+HIPO-

Description:

HIV-seropositive with lipodystrophy and no use of lipid-lowering drugs.

LIPO+HIPO+

Description:

HIV-seropositive with lipodystrophy and use of lipid-lowering drugs.

Treatment:

Drug: use of lipid-lowering drugs.