Engineering Immune Organoids to Study Pediatric Cancer (IMMUNEORGANOID)

Gustave Roussy

Status

Enrolling

Conditions

Sarcoma

Neuroblastoma

Kidney Tumor

Brain Tumor

Treatments

Procedure: Skin biopsy

Procedure: Healthy tissue from the tumor

Biological: Blood sample

Procedure: Spinal cerebrospinal fluid (SCF)

Procedure: Fresh tumor sample

Study type

Interventional

Funder types

Other

Identifiers

2020-A03021-38

2020/3712 (Other Identifier)

Details and patient eligibility

About

To engineer immune organoids from pediatric patient tissues using induced-pluripotent stem cells (iPSC)

Enrollment

44 estimated patients

Sex

All

Ages

Under 25 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age at diagnosis ≤ 25 years except for patients with malignant gliomas and renal tumors for whom no upper age limit is applied
Medical suspicion or diagnosis of one of the following diseases, regardless of stage:
Brain tumors
Renal tumors
Neuroblastoma
Sarcomas
Adult patient or parents or guardians should understand, sign and date the appropriate written informed consent from prior to any protocol-specific procedures performed. Patient should be able and willing to comply with study visits and procedures as per protocol.
Affiliated to a social security system or beneficiary of the same.

Exclusion criteria

Any histology not mentioned in the inclusion criteria
Adult patient or parents/guardians incapable/incapable of giving its/their consent
Patients deprived of their liberty by a judicial or administrative decision