Enhanced Recovery After Surgery for SPK Transplantation Recipients

Second Affiliated Hospital of Guangzhou Medical University

Status: Completed

Conditions: Diabetic Nephropathy; Perioperative/Postoperative Complications; Transplant Complication

Treatments: Procedure: Enhanced recovery for SPK recipients

Study type: Interventional

Funder types: Other

Identifiers

NCT06095544

2020-hs-67

Details and patient eligibility

About

108 patients underwent elective SPK surgery were randomly divided into ERAS group (E) and routine care group (T). The ERAS group was consisted of evidenced-based systematic optimization approaches, while the control group received routine care.

Full description

Primary results: the postoperative length of stay (LoS) and hospitalization costs; second results: post-operative analgesia score (NRS) , the incidence of post-operative nausea and vomiting (PONV) , urinary catheter removal time by 7 days , post-operative gastric tube indwelling time, the incidence of ambulation within 6 days . the dosage of dobutamine using , the dosage of norepinephrine using, and the total amount of fluid and urine volume . MAP and lactate level . Peak systolic velocity (PSV) and (resistance index) RI of grafts were checked between two groups.

Enrollment: 90 patients

Sex: All

Ages: 20 to 62 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients were aged 20-62 years
2. Body mass index (BMI) of 18.5-32.9 kg/m2
3. Voluntary participation for elective SPK surgery
4. ERSD and DN patients waiting for SPK transplantation surgery.

Exclusion criteria

1. History of allergy to narcotic drugs
2. cardiopulmonary insufficiency
3. congestive heart failure
4. myasthenia gravis
5. neurological disease
6. mental illness
7. severe liver dysfunction
8. hyperkalaemia
9. malignant hyperthermia
10. unwilling to participate in the study for any reason, or had participated in another study within the 3 months

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 2 patient groups

ERAS group

Experimental group

Description:

ERAS group was consisted of evidenced-based systematic optimization approaches

Treatment:

Procedure: Enhanced recovery for SPK recipients

Traditional group

No Intervention group

Description:

The control group received routine care