Enhanced Recovery After Surgery Promotes the Rehabilitation of Patients With Acute Gastrointestinal Perforation in Perioperative Period

Hebei Medical University

Status: Completed

Conditions: Acute Gastrointestinal Perforation; Enhanced Recovery After Surgery

Treatments: Behavioral: Traditional treatment methods.; Behavioral: The enhanced recovery after surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT07008313

HebMU 20180065

Details and patient eligibility

About

The enhanced recovery after surgery(ERAS) has been gradually extended from its initial colorectal surgery to almost all surgical fields. However, there are few reports about the application value of ERAS in emergency surgery. The goal of this clinical trial is to evaluate the value of ERAS in the perioperative period of acute gastrointestinal perforation. All the patients will be treated by emergency operation. The changes of CRP, PA, PCT in Plasma 1 hour before operation and 1,3,7 days after operation, the operation time, the amount of bleeding during operation, the recovery time of intestinal function and the time of the first meal after operation,the incidence of postoperative complications, the degree of postoperative pain, the time of first out-of-bed activity, fatigue and mental status, quality of life, the length and the cost of hospital stay will be monitored and recorded.

Enrollment: 362 patients

Sex: All

Ages: 14 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age≥14years old and ≤80 years old
• The initial diagnosis is acute gastrointestinal perforation

Exclusion criteria

• Patients with unconsciousness,or patients with past psychiatric history
• Patients with shock and/or severe organ failure
• Patients who are pregnant
• Patients with severe spinal deformity who are unable to receive epidural anesthesia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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362 participants in 2 patient groups, including a placebo group

the enhanced recovery after surgery (ERAS) group

Experimental group

Description:

Patients were rehabilitated using the ERAS concept.

Treatment:

Behavioral: The enhanced recovery after surgery

the conventional surgical treatment (CST) group

Placebo Comparator group

Description:

Traditional treatment methods.

Treatment:

Behavioral: Traditional treatment methods.