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Enhancing Exposure Therapy for Snake and Spider Phobias (Snake/Spider)

The University of Texas System (UT) logo

The University of Texas System (UT)

Status and phase

Completed
Phase 2
Phase 1

Conditions

Specific Phobia

Treatments

Behavioral: Exposure Therapy with Retrieval and Compound Extinction
Behavioral: Exposure Therapy with Retrieval
Behavioral: Therapist-guided Exposure Therapy
Behavioral: Exposure Therapy with Compound Extinction

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT02160470
2011-10-0012
1F31MH100760-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study tests whether exposure therapy for fear of snakes or spiders is enhanced by the addition of a brief fear retrieval trial prior to treatment, and the use of compound extinction during treatment. The goal of the study is to determine whether these behavioral techniques enhance the efficacy of exposure therapy, one of the most empirically supported treatments for anxiety disorders.

Full description

This study tests whether exposure therapy for fear of snakes or spiders is enhanced by the addition of a brief fear retrieval trial prior to treatment, and the use of compound extinction during treatment. The goal of the study is to determine whether these behavioral techniques enhance the efficacy of exposure therapy, one of the most empirically supported treatments for anxiety disorders. Individuals between the ages of 18-65 with elevated fear of spiders or fear of snakes are randomly assigned to one of four treatment conditions (1) standard exposure therapy, (2) exposure therapy with fear retrieval augmentation, (3) exposure therapy with compound extinction augmentation, and (4) exposure therapy with fear retrieval and compound extinction augmentations. All participants undergo an online prescreen and a face-to-face screening assessment to determine eligibility and baseline (pre-treatment) symptom severity. Participants additionally complete assessments directly after treatment (post-treatment), and approximately one week after treatment (follow-up). The pre-treatment assessment occurs 1-14 days prior to treatment, the post-treatment assessment occurs during the treatment visit as soon as the treatment procedure is complete, and the follow-up assessment occurs within a window of 6-14 days after the completion of treatment. Participants complete two behavioral approach tests (in the treatment context and in the generalization context) at pre-treatment, post-treatment, and follow-up. Participants complete a battery of self-report questionnaires at pre-treatment and follow-up.

Enrollment

120 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Age 18 to 65.
  2. Speaks English fluently.
  3. A score of 70 or higher on the Fear of Snakes/Spiders Questionnaire.
  4. Demonstrates avoidance during behavioral approach tests (defined as inability to put palm flat on the bottom of a tank containing a snake/spider, and inability to touch a snake/spider with a bare finger).

Exclusion criteria

  1. Unstable dose of psychotropic medications during the 4 weeks prior to baseline assessment.
  2. Currently receiving exposure-based treatment for snake/spider phobia.
  3. Currently at risk for suicide.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Factorial Assignment

Masking

None (Open label)

120 participants in 4 patient groups

Exposure with Retrieval
Experimental group
Description:
Exposure Therapy with Retrieval
Treatment:
Behavioral: Exposure Therapy with Retrieval
Exposure with Compounding
Experimental group
Description:
Exposure Therapy with Compound Extinction
Treatment:
Behavioral: Exposure Therapy with Compound Extinction
Exposure with Retrieval and Compounding
Experimental group
Description:
Exposure Therapy with Retrieval and Compound Extinction
Treatment:
Behavioral: Exposure Therapy with Retrieval and Compound Extinction
Therapist-Guided Exposure Therapy
Active Comparator group
Description:
Therapist-guided Exposure Therapy
Treatment:
Behavioral: Therapist-guided Exposure Therapy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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