Enhancing Prospective Thinking in Early Recovery (BEAM)

Indiana University

Status: Enrolling

Conditions: Alcohol Use Disorder

Treatments: Behavioral: Low-Intensity Cue; Behavioral: High-Intensity Cue

Study type: Interventional

Funder types: Other

Identifiers

NCT06283472

2P60AA007611 (U.S. NIH Grant/Contract)

1805574553 Aims 14-16;

2P60AA007611-403343 (Other Grant/Funding Number)

Details and patient eligibility

About

The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question[s] this trial aims to answer are:

• Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues?
• Will high-intensity EFT cues effect greater treatment-seeking interest?
• Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity)
• Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS?
• Will the novel behavioral SS decision-making task activate the nucleus accumbens?

Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.

Enrollment: 21 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals who meet current heavy drinking (≥2 heavy drinking days/month OR ≥7 drinks/week for biological females, and ≥14 drinks/week if biological male [NIAAA definition] and/or AUDIT scores ≥8)
• English comprehension

Exclusion criteria

• Unstable medical disorders
• Outside the age range of 18-60
• Smell/taste disorders
• Unstable psychiatric conditions

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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21 participants in 2 patient groups

High-Intensity

Experimental group

Description:

Participants will receive high-intensity episodic future-thinking cue images, and high-intensity episodic recent-thinking cue images during an MRI decision-making task.

Treatment:

Behavioral: High-Intensity Cue

Low-Intensity (Control)

Active Comparator group

Description:

Participants will receive low-intensity episodic future-thinking cue images, and low-intensity episodic recent-thinking cue images during an MRI decision-making task.

Treatment:

Behavioral: Low-Intensity Cue