Enhancing Recovery After Cardiac Surgery

University of California, Los Angeles (UCLA)

Status: Completed

Conditions: Coronary Artery Disease; Depression

Treatments: Behavioral: Usual Care; Behavioral: Cognitive Behavioral Therapy (CBT)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00522717

R01NR009228 (U.S. NIH Grant/Contract)

5R01NR009228-02

Details and patient eligibility

About

Patients recovering from coronary artery bypass graft (CABG) surgery have high rates of depression, and depression is associated with higher risk of complications and death. Recent discoveries show that depression involves changes in certain molecules in the blood, which are also involved in progressive coronary artery disease (CAD) and its complications. This study will evaluate the effects of cognitive behavioral therapy (CBT) as a treatment for depression on these biological markers among CABG patients.

Enrollment: 808 patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergone CABG at one of our recruitment sites

Exclusion criteria

• Less than 45 years of age
• Have cognitive impairment or major comorbid psychiatric conditions
• Have autoimmune disorder or malignancy
• Currently smoking

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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808 participants in 2 patient groups

1

Experimental group

Treatment:

Behavioral: Cognitive Behavioral Therapy (CBT)

2

Active Comparator group

Treatment:

Behavioral: Usual Care