Enhancing Renal Graft Function During Donor Anesthesia

Nazmy Edward Seif

Status: Enrolling

Conditions: Renal Failure Chronic; Transplant;Failure,Kidney; Anesthesia

Treatments: Procedure: Adequate hydration; Procedure: Mannitol infusion; Procedure: Dopamine infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT03778944

RGFEDDA

Details and patient eligibility

About

Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess & compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• end-stage renal disease, for living-donor kidney transplantation

Exclusion criteria

• severe cardiac or hepatic dysfunction
• coagulopathy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

M group

Active Comparator group

Description:

Mannitol infusion

Treatment:

Procedure: Mannitol infusion

D group

Active Comparator group

Description:

Dopamine infusion

Treatment:

Procedure: Dopamine infusion

C group

Active Comparator group

Description:

Adequate hydration

Treatment:

Procedure: Adequate hydration