Enhancing Sensorimotor Processing in Children With Dystonia

King's College London

Status

Not yet enrolling

Conditions

Dystonia; Idiopathic

Dystonia

Dystonic Cerebral Palsy

Dystonia, Primary

Dystonia, Secondary

Treatments

Other: No intervention

Study type

Observational

Funder types

Other

Identifiers

NCT05612464

317454

Details and patient eligibility

About

Dystonia is a severely disabling movement disorder with no cure, in which people suffer painful muscle spasms causing twisting movements and abnormal postures. There are many causes, including genetic conditions and brain injury. The most common cause in childhood is dystonic cerebral palsy (CP) which often affects the whole body.

The underlying mechanisms are unknown, but there is growing evidence to implicate abnormal brain processing by the brain of incoming "sensory" information (e.g., signals to the brain from our senses of touch and body position): the distorted perception of these signals disrupts the way the brain produces instructions for planning and performing movements.

The investigator's previous studies have shown that the way the brain processes sensory information related to movement is abnormal in children with dystonia and dystonic CP, by using methods that record the EEG (electroencephalogram - brain wave signals) and/or EMG (electromyogram - electrical signal from muscles). A specific brain rhythm (called mu) typically shows well-defined changes in response to movement, and reflects processing of sensory information. The investigator's work shows these rhythm changes are abnormal in children with dystonia/dystonic CP.

This study will explore if these findings can improve treatment. In particular the study team will investigate whether children and young people with dystonia/dystonic CP can enhance these mu rhythm responses during a movement task by using feedback of their brain rhythms displayed as a cartoon/game on a computer. The investigators will also assess whether enhanced mu activity is associated with improved movement control. This would open future possibilities to use such devices for therapy/rehabilitation.

Children and young people with dystonia/dystonic CP aged 5-25 years will be recruited, along with age-matched controls. Studies will last 2-3 hours with time for breaks and will be conducted at Evelina London Children's Hospital and Barts Health Trust, with the option for home visits if preferable for families.

Enrollment

90 estimated patients

Sex

All

Ages

5 to 25 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Key inclusion criteria

Control Group:

Age 5 -25 years
No known disorder of movement
Able to understand and participate in study.

Primary dystonia group (isolated genetic or idiopathic):

Age 5-25 years
Clinical dystonia - as confirmed on clinical assessment by consultant paediatric neurologist.
Genetic or idiopathic aetiology.
No other neurological abnormality.
Normal cranial magnetic resonance imaging (MRI).
Able to understand and participate in study.

Dystonic Cerebral Palsy Group:

Age 5-25 years
Clinical dystonia/dyskinesia - as confirmed on clinical assessment by consultant paediatric neurologist.
Documented history of perinatal hypoxic-ischaemic encephalopathy (HIE), prematurity <35 weeks or kernicterus.
Predominant dystonia/dyskinesia / Minimal spasticity
MRI findings in keeping with acute perinatal HIE, prematurity or kernicterus (including classical pattern of damage to thalami, basal ganglia and peri-rolandic cortex, periventricular leukomalacia or ischaemic parenchymal injury).
Able to understand and participate in study.

Key exclusion criteria

Control Group: