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Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation

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VA Office of Research and Development

Status

Completed

Conditions

Alzheimer's Disease
Mild Cognitive Impairment

Treatments

Device: Transcranial direct current stimulation (tDCS)

Study type

Interventional

Funder types

Other U.S. Federal agency

Identifiers

NCT01958437
C1381-P

Details and patient eligibility

About

Remembering how to travel from one location to another is critical in everyday life, yet this vital ability declines with normal aging and can be further affected by conditions that disproportionately affect the elderly, such as vision loss or progressive dementia. Human and animal research has shown that two distinct memory systems interact during navigation. The first, referred to as allocentric navigation, is very flexible and uses spatial knowledge of key features or landmarks to develop and use a mental map of the environment. This approach involves brain regions that are critical for new learning and memory but that decline with age. The second, referred to as egocentric navigation, is inflexible and relies on "habit" memories that link specific features with specific directions. This approach relies on brain regions that are critical for "automatic" responses and that are relatively unaffected by age.

The main problem is that allocentric navigation declines with age and is accompanied increased dependence on egocentric navigation. This change increases the risk of becoming disoriented or "lost" when traveling in unfamiliar areas or even when traveling new routes in familiar areas. Therefore, the main goal of this project is to examine whether non-invasive brain stimulation, specifically transcranial direct current stimulation, can improve allocentric navigation in healthy older adults and patients with mild cognitive impairment.

Participants will complete two functional magnetic resonance imaging sessions while learning new environments. Before one of these sessions, participants will receive active brain stimulation over the parietal cortex. Before the other session, participants will receive sham brain stimulation over the parietal cortex. The effects of this stimulation will be evaluated using both an allocentric and an egocentric memory test. Physiologic effects will be evaluated using both task-based and resting-state MRI.

Enrollment

44 patients

Sex

All

Ages

50 to 88 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

General inclusion criteria (all participants):

  • All medications stable for approximately 1-2 months;
  • No history of severe mental illness;
  • No current untreated alcohol or substance abuse/dependence;
  • English as native and preferred language;
  • MRI-compatible if taking part in fMRI studies
  • Able to give informed consent.

MCI Inclusion Criteria:

  • Diagnosis of amnestic MCI based on criteria set forth by Petersen (2004). Additionally, other potential causes of cognitive deficit ruled out by the referring physician;

Healthy older adults

  • intact cognitive functioning as measured by neuropsychological testing

Exclusion criteria

  • History of neurological disease or injury
  • History of severe mental illness
  • Current untreated alcohol or substance abuse
  • Other conditions may exclude; please discuss with contact

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

44 participants in 4 patient groups

Cognitively intact older adults - ACTIVE tDCS
Experimental group
Description:
Group receives active brain stimulation
Treatment:
Device: Transcranial direct current stimulation (tDCS)
MCI ACTIVE tDCS
Active Comparator group
Description:
Group receives active brain stimulation
Treatment:
Device: Transcranial direct current stimulation (tDCS)
Cognitively intact older adults - SHAM tDCS
Sham Comparator group
Description:
Group receives sham brain stimulation
Treatment:
Device: Transcranial direct current stimulation (tDCS)
MCI SHAM tDCS
Sham Comparator group
Description:
Group receives sham brain stimulation
Treatment:
Device: Transcranial direct current stimulation (tDCS)

Trial documents
1

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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