Enteral Feeding and Early Gut Colonization of Preterm Infants (PRECOL)

Universidad Complutense de Madrid

Status: Completed

Conditions: Premature Birth of Newborn

Study type: Observational

Funder types: Other

Identifiers

NCT02502916

PROBILAC/12O_2

Details and patient eligibility

About

The aim of this study is to evaluate the potential role of the enteral feeding systems on the bacterial colonization of premature infants during their NICU admittance and its evolution after 2 years, which is the age when the infant's gut starts to contain an adult-like microbiota.

Full description

First spontaneously evacuated meconium and fecal samples were collected by the medical staff of the Hospital weekly from the diapers of the infants during their stay at the Neonatal Intensive Care Unit.

To evaluate the potential role of the enteral feeding systems as a site for colonization by nosocomial bacteria, and, its impact on early gut colonization of preterm neonates, mother's own milk, donor milk and preterm formula samples were obtained after passing through the external part of the enteral feeding tubes and cultured.

Later, when the infants reached 2 years of age, parents were contacted by phone to provide an additional fecal sample if their infants had not taken antibiotics within the previous 2 months.

Enrollment: 32 patients

Sex: All

Ages: 2 to 8 hours old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• gestational age of less than 32 weeks or with birth weight of less than 1,200 g

Exclusion criteria

• any malformation or suffering from any genetic metabolic disorder

Trial design

32 participants in 1 patient group

Preterm infant

Description:

Preterm infants born from October 2009 to June 2010 at a gestational age of less than 32 weeks or with birth weight of less than 1,200 g