Environmental Exposure and Neurological Diseases Questionnaire (Cleveland Ohio)

Dartmouth Health

Status: Completed

Conditions: Amyotrophic Lateral Sclerosis

Treatments: Other: Patient Registry

Study type: Observational

Funder types: Other

Identifiers

NCT02916966

D06019

Details and patient eligibility

About

The proposed research is particularly relevant to the National ALS Registry and public environmental health issues because it addresses the potential environmental causes of sporadic ALS. The research will develop an ALS surveillance program in Ohio that can be compared with the national and State-Metro Surveillance Programs of the National ALS Registry, and novel methodologies to determine the role of the cyanobacterial toxin, BMAA (beta-methylamino-L-alanine), and other environmental toxins/toxicants as risk factors for ALS. This work will advance the mission of the Centers for Disease Control Agency for Toxic Substances and Disease Registry (CDC ATSDR) National ALS Registry by offering data on ALS cases in Ohio that address public health concerns over the effects of chronic exposure to cyanobacterial blooms in Lake Erie.

Enrollment: 460 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ALS
• Non-neurodegenerative controls
• Can willingly give consent
• Over 18 years of age

Exclusion criteria

• Cannot give consent
• Under 18 years of age

Trial design

460 participants in 4 patient groups

ALS Patients in Case-Control

Description:

ALS patients enrolled by Cleveland Clinic Foundation (CCF)

Treatment:

Other: Patient Registry

Non-neurodegenerative patients in case control

Description:

Non-neurodegenerative patients enrolled by CCF

Treatment:

Other: Patient Registry

Non-neurodegeneration population in population control

Description:

Non-neurodegenerative general population enrolled by ABS mailing system from DHMC

Treatment:

Other: Patient Registry

ALS Patients in State of OH

Description:

ALS registry of all cases in Ohio

Treatment:

Other: Patient Registry