Environmental Risk Factors in Multiple Sclerosis Development: Epidemiological Study of EBV Infection and Vitamin D Deficiency in RIS Patients (RIS - EBVD)

Centre Hospitalier Universitaire de Nīmes

Status

Completed

Conditions

Radiologically Isolated Syndrome

Epstein-Barr Virus Infections

Treatments

Other: Antibiody titration

Study type

Observational

Funder types

Other

Identifiers

NCT07256431

LOCAL/2025/PROBIORIS/EBVD

Details and patient eligibility

About

This is an ancillary study using samples collected in the ProBioRIS cohort (NCT06395662). The aim of the project is to highlight new biomarker candidates to assess the risk of conversion to clinically definite multiple sclerosis (CDMS) and disease activity (Evidence of Disease Activity) by taking into account demographic, clinical and MRI parameters. A cohort of healthy subjects will be integrated into the study to serve as a control population. We will study a panel of serum immunoglobulins targeting different Epstein Barr virus antigens to identify latency or reactivation phases. Identifying and prioritizing risk factors for clinical conversion to MS in radiologically isolated syndrome patients is of major importance for the implementation of personalized monitoring and treatment strategies, especially following the recent highlighting of the benefit of background treatments in patients at high risk of CDMS.

Enrollment

110 patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

RIS patients from the ProBioRIS study with sufficient serum residuals for vitamin D testing and complete EBV serology.
Healthy subjects who participated in the VDSS trial and who provided consent for the use, for basic research purposes, of human biological samples collected during the trial.

Exclusion criteria

• Insufficient sample