Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors

Pediatric Brain Tumor Consortium

Status and phase

Completed

Phase 1

Conditions

Neuroblastoma

Brain and Central Nervous System Tumors

Treatments

Drug: enzastaurin hydrochloride

Study type

Interventional

Funder types

NETWORK

NIH

Identifiers

NCT00503724

CDR0000557572

U01CA081457 (U.S. NIH Grant/Contract)

PBTC-023 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Enzastaurin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

PURPOSE: This phase I trial is studying the side effects and best dose of enzastaurin in treating young patients with refractory primary brain tumors.

Full description

OBJECTIVES:

Primary

To estimate the maximum tolerated dose (MTD) and/or recommend a phase II dose of enzastaurin hydrochloride in children with recurrent or refractory CNS tumors who are not receiving enzyme-inducing anticonvulsants.
To further characterize the pharmacokinetics and toxicity of the recommended phase II dose of enzastaurin hydrochloride given twice daily in these patients.

Secondary

To characterize the pharmacokinetics of enzastaurin hydrochloride at the recommended phase II dose given once a day or twice a day in children.
To document and describe toxicities associated with enzastaurin hydrochloride.
To document antitumor activity in children with recurrent or refractory CNS tumors.
To explore changes in MR perfusion scans obtained within 15 ± 2 days after initiation of enzastaurin hydrochloride therapy as compared to baseline and to correlate these changes with clinical outcome.
To evaluate a panel of biological surrogate markers in this patient population at baseline and following enzastaurin hydrochloride administration.

OUTLINE: This is a multicenter study.

Patients receive oral enzastaurin hydrochloride once daily until the maximum tolerated dose (MTD) is determined. Patients then receive enzastaurin hydrochloride at the MTD twice daily on days 1-28. Treatment repeats every 28 days for 13 courses in the absence of disease progression or unacceptable toxicity. Patients may receive 13 additional courses (for a total of 26 courses) of oral enzastaurin hydrochloride if the patient is benefitting from the treatment and the investigator and subject agree to continue treatment.

Patients undergo blood sample collection periodically for pharmacokinetic studies.

After completion of study treatment, patients are followed periodically.

Enrollment

32 patients

Sex

All

Ages

Under 21 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Histologically confirmed primary CNS malignancy including low-grade glioma
- All tumors, except intrinsic brain stem and diffuse optic pathway tumors, must have histological verification at either the time of diagnosis or recurrence
  - Patients with intrinsic brain stem or diffuse optic pathway tumors must have clinical and/or radiographic evidence of progression
Recurrent or progressive disease or disease refractory to standard therapy and for which there is no known curative therapy

PATIENT CHARACTERISTICS:

Inclusion Criteria:

Karnofsky performance scale (for > 16 years of age) or Lansky performance score (for ≤ 16 years of age) ≥ 60% assessed within two weeks prior to registration
Peripheral absolute neutrophil count (ANC) ≥ 1,000/μL
Platelet count ≥ 100,000/μL (transfusion independent)
Hemoglobin ≥ 8.0 g/dL (may receive RBC transfusions)
Creatinine clearance or radioisotope GFR ≥ 70 mL/min OR maximum serum creatinine based on age as follows:
- 0.8 mg/dL (≤ 5 years of age)
- 1.0 mg/dL (6 to 10 years of age)
- 1.2 mg/dL (11 to 15 years of age)
- 1.5 mg/dL (≥ 16 years of age)
Total bilirubin ≤ 1.5 x upper limit of normal (ULN) for age
ALT ≤ 5 x ULN for age
Serum albumin ≥ 2.5 g/dL
Patients of childbearing or child-fathering potential must be willing to use a medically acceptable form of birth control, which includes abstinence, while being treated on this study
Negative pregnancy test
Patients must have a normal QTc for age and no evidence of a clinically significant arrhythmia on ECG
No evidence of active graft-versus-host disease

Exclusion Criteria:

Pregnant or lactating
Body surface area < 0.5 m^2
Clinically significant unrelated systemic illness that would compromise the patient's ability to tolerate protocol therapy or would likely interfere with the study procedures or results
Known hypersensitivity to enzastaurin hydrochloride or its components
Inability to return for follow-up visits or obtain follow-up studies required to assess toxicity to therapy

PRIOR CONCURRENT THERAPY:

Inclusion Criteria:

Must have recovered from the acute toxic effects (grade ≤ 2) of all prior therapy before entering this study
Must not have received myelosuppressive chemotherapy within 3 weeks of entry onto this study (6 weeks for prior nitrosourea)
At least 7 days since the completion of therapy with a hematopoietic growth agent (i.e., filgrastim [G-CSF], sargramostim [GM-CSF], or erythropoietin)
- At least 14 days since long-acting formulations
- Therapeutic use of myeloid growth factors in patients with serious neutropenic conditions, such as sepsis, may be considered at the investigator's discretion
At least 7 days since the completion of therapy with a biologic agent
At least 2 weeks since prior local palliative radiotherapy (small port)
At least 6 months must have elapsed after prior total body irradiation (TBI) or craniospinal radiotherapy
At least 6 weeks must have elapsed after other substantial bone marrow irradiation
At least 6 months since prior allogeneic bone marrow transplantation
At least 3 months since prior autologous bone marrow or stem cell transplantation
Patients who are receiving dexamethasone must be on a stable or decreasing dose for at least 1 week prior to registration
- Corticosteroids should be used at the lowest dose to control symptoms of edema and mass effect

Exclusion Criteria:

Routine concurrent use of growth factors (i.e., G-CSF, GM-CSF, or erythropoietin)
Any other concurrent anticancer or investigational drug therapy
Concurrent enzyme-inducing anticonvulsants (EIACDs)
Concurrent gents that prolong the QTc
Concurrent drugs that are substrates or inhibitors of CYP3A4 or CYP2C9
Other concurrent drugs that are sensitive substrates of CYP2C8, CYP2C9, or CYP2C19 and/or have a narrow therapeutic window