Enzyme Activity of Matrix Metalloproteinases in the Serum of Patients With Malignant Obstructive Hyperbilirubinemia Before and After PTBD

Institut za Rehabilitaciju Sokobanjska Beograd

Status: Unknown

Conditions: Matrix Metalloproteinase

Treatments: Procedure: Percutaneous biliary drainage

Study type: Observational

Funder types: Other

Identifiers

NCT04801914

717/11

Details and patient eligibility

About

The purpose of this study is to detect differences in the enzymatic activity of matrix metalloproteinases in patients with malignant obstructive hyperbilirubinemia before and after percutaneous biliary drainage.

Full description

This study will be designed as a prospective cohort study involving the collection of peripheral blood samples before and one month after percutaneous biliary drainage for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity). Biochemical analyzes are preceded by the entry of data relevant to the research (demographic, anamnestic, clinical and biochemical).

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

pathological confirmation or imaging data confirming malignant disease causing bile duct obstruction, performance status 0-1

Exclusion criteria

terminally ill patients, performance status >2, hepatic decompensation, severe underlying cardiac or renal diseases and coagulation disorders.

Trial design

30 participants in 1 patient group

Matrix Metalloproteinases

Description:

Value of serum matrix metalloproteinase activity before and one month after PTBD

Treatment:

Procedure: Percutaneous biliary drainage