EORTC-endorsed, Prospective European Multicenter Imaging Survey and Protocol

Ludwig Maximilian University of Munich

Status: Unknown

Conditions: Metastatic Colorectal Cancer

Treatments: Other: Facilitation; Other: Imaging survey

Study type: Observational

Funder types: Other

Identifiers

NCT04656782

EORTC imaging survey

Details and patient eligibility

About

A prospective, multicenter imaging Delphi survey among European radiological societies for mCRC imaging standardization.

Full description

BACKGROUND: Computed Tomography (CT) is the imaging reference standard for initial staging and response assessment in randomized, controlled clinical trials (RCT) dealing with metastatic colorectal cancer (mCRC). However, comparability of imaging data among recruiting centers in RCTs is highly hampered by diverging imaging protocols and different technical specifications. Over the last years, analysis of radiomic features in mCRC patients has gained increasing interest for image evaluation beyond the mere assessment of extent. Also, these radiomic features are highly susceptible to technical parameters such as slice thickness. Hence, comparability of radiomic features among recruiting centers are also highly limited due to diverging imaging protocols.

AIMS: This prospective, multicenter imaging survey aims at assessing current differences regarding mCRC CT imaging protocols and technical specifications among large academic sites in Europe and at drafting a consensus imaging protocol endorsed by the European Organisation for Research and Treatment of Cancer (EORTC).

METHODS: This survey will be in close cooperation of the EORTC Imaging Group, EORTC Gastro-intestinal Tract Group, European Society of Oncologic Imaging (ESOI) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR). Among the EORTC Imaging Group, EORTC Gastro-intestinal Tract Group, ESOI and ESGAR, imaging experts will be prospectively recruited and will serve as expert panelists in this prospective survey. Following the Delphi approach for survey conduction, several survey rounds will be performed. The answers of each survey round will be analyzed by the survey facilitators, blinded results will then be forwarded to the expert panelists prior to every following survey round. Statements / answers can then be modified by the expert panelists in the following survey round.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Researchers / academics with expertise in gastro-intestinal / oncologic imaging
• Association with EORTC Imaging Group, EORTC GI Group, ESGAR or ESOI.

Exclusion criteria

• Participants not meeting the inclusion criteria

Trial design

40 participants in 2 patient groups

Expert panelists

Description:

Expert panelists will be recruited from EORTC Imaging Group, EORTC GI Group, ESOI and ESGAR and will actively participate in the imaging survey rounds.

Treatment:

Other: Imaging survey

Facilitators

Description:

The two central facilitators will moderate and guide the survey rounds. Blinded results will be forwarded to the expert panelists by the facilitators. Further Survey rounds will be adapted by the facilitators according to the previous answers given by the panelists.

Treatment:

Other: Facilitation