Eosinophils in Human Adipose Tissue

Mayo Clinic

Status

Invitation-only

Conditions

Insulin Resistance

Obesity

Treatments

Procedure: endoscopy sleeve gastroplasty

Study type

Interventional

Funder types

Other

Identifiers

NCT04898400

21-000959

Details and patient eligibility

About

The purpose of this study is to better understand the interactions between the innate immune system, in particular eosinophils (EOS), and adipose tissue (AT) in human health and in disease states such as obesity and insulin resistance.

Enrollment

12 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Obesity (BMI>30 kg/m2).
Evidence of insulin resistance as defined by hemoglobin A1c > 5.7%.
Mayo Clinic patients evaluated by Dr. Rahul Pannala.
Pursue an endoscopic gastroplasty at Mayo Clinic Arizona in the Gastroenterology department.
Equal distribution of gender.
18 yo older of age.
BMI>30 kg/m2.
Nonsmoker.
Taking no medication affecting glucose or lipid metabolism.
No more than 5% change in body weight in the previous 6 months.
Mostly sedentary (engaging in strenuous exercise (> 70% max HR) less than 3 times a week).
Not be receiving corticosteroid therapy.
Have no history of asthma, COPD or atopic syndrome, or autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).

Exclusion criteria

<17 years of age.
BMI <30 kg/m2.
Smoker.
Taking medication affecting glucose or lipid metabolism.
Greater than 5% change in body weight within the previous six months.
Engage in strenuous exercise (>70% max HR) less than 3 times a week.
Receiving corticosteroid therapy.
Have a history of asthma.
History of COPD or atopic syndrome.
History of autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).