Epidemiological Study of Chronic Thromboembolic Pulmonary Hypertension in China

Air Force Military Medical University of People's Liberation Army

Status: Unknown

Conditions: To Assess the Long-term Risk for Adverse Events After PE.

Study type: Observational

Funder types: Other

Identifiers

NCT01717092

XJ-CTPH20121026

Details and patient eligibility

About

Chronic thromboembolic pulmonary hypertension (CTPH) is associated with considerable morbidity and mortality. Its incidence after pulmonary embolism and associated risk factors are not well documented in Chinese population. We conducted a prospective, long-term, follow-up study to assess the incidence of symptomatic CTPH in consecutive patients with an acute episode of pulmonary embolism but without prior venous thromboembolism. Patients with unexplained persistent dyspnea during follow-up underwent transthoracic echocardiography and, if supportive findings were present, ventilation-perfusion lung scanning and pulmonary angiography. CTPH was considered to be present if systolic and mean pulmonary-artery pressures exceeded 40 mm Hg and 25 mm Hg, respectively; pulmonary-capillary wedge pressure was normal; and there was angiographic evidence of disease.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with an episode of acute symptomatic pulmonary embolism without prior pulmonary embolism or venous thrombosis

Exclusion criteria

• Have other diseases (e.g., systemic sclerosis or severe emphysema) that could have caused nonthromboembolic pulmonary hypertension,
• Have preexisting exertional dyspnea,
• Geographically inaccessible for follow-up,
• Decline to participate in the study.

Trial design

400 participants in 1 patient group

Consecutive patients with acute PE