Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care (EurobactII)

Outcome Rea

Status: Completed

Conditions: Hospital Acquired Condition; Bacteremia; Resistance Bacterial; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT03937245

EurobactII

Details and patient eligibility

About

Eurobact II will investigate the mortality and morbidity of hospital-acquired blood stream infections in patients treated in intensive care units (ICU). It will investigate the effects of the micro-organism and its characteristics, such as type and resistance to antibiotics on the infection and its consequences. It will also investigate the effects of the antibiotics and other treatments on survival of patients. Eurobact II will include patients from multiple ICUs in multiple countries.

Full description

Eurobact II is a multinational multicentre cohort study that will include patients with hospital-acquired blood stream infections (HA-BSI) treated in ICUs around the globe. It will provide with an update of the epidemiology of HA-BSI since the Eurobact I study. It is designed to investigate the effects of HA-BSI on mortality at day 28. To describe the determinants of outcomes of HA-BSI, specifically the effects of the source of infection, the microorganism, the characteristics of antimicrobial therapy and of source control. It will investigate patient specific and organizational factors and will describe the determinants of management of HA-BSI in ICUs.

Enrollment: 3,058 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 Years.

• Hospital Acquired Bloodstream Infection (HA-BSI).

• Treated in the ICU.

  • ICU acquired OR
  • Hospital acquired prior to ICU admission

Exclusion criteria

• Patients that had a positive blood culture in the hospital and transferred to ICU for a different reason than specific treatment of the causes or consequences of HA-BSI.

• Previous inclusion in the study.

  • HA-BSI is defined as a positive blood culture (BC) sampled after 48 hours following hospital admission.

Trial design

3,058 participants in 1 patient group

HA-BSI

Description:

Patients with HA-BSI treated in an ICU