Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America (LATAM-AKID)

The University of Alabama at Birmingham

Status: Begins enrollment this month

Conditions: AKI; Dialysis; Renal Replacement Therapy; Acute Kidney Injury; Renal Replacement Therapy for Acute Kidney Injury in ICU; Critically Ill Acute Kidney Injury

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT07262320

IIR from Vantive (Other Grant/Funding Number)

IRB-300013633

Details and patient eligibility

About

This is an international, multicenter, observational study aimed at investigating acute kidney injury requiring renal replacement therapy (AKI-RRT) in Latin American countries. The main questions this study aims to answer are:

• What is the epidemiology, outcomes, and processes of care for patients with AKI-RRT in Latin America?
• How do outcomes differ across different countries in Latin America?
• What factors (demographics, clinical, socioeconomic) influence outcomes in patients with AKI-RRT in Latin America?

The main aims of this study are to:

• Establish a comprehensive database containing clinical, laboratory, treatment, process, and outcome data of patients with AKI-RRT in Latin America
• Describe current epidemiology of AKI-RRT in Latin America
• Compare processes of care and outcomes across different countries in Latin America
• Provide data resources to facilitate and promote clinical research in AKI-RRT

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient (≥18) admitted to the ICU
• First ICU admission during current hospitalization
• Diagnosis of acute kidney injury stage 3 according to KDIGO guidelines
• RRT initiated no earlier than 3 days before or no later than 7 days after ICU admission

Exclusion criteria

• Transfer from outside hospital with ongoing RRT
• RRT exposure of less than 2 days (if CRRT or PD was provided) or less than 2 HD/SLED sessions
• Kidney failure (ESRD) patients on maintenance dialysis
• Kidney transplant recipients
• Previous or new diagnosis of glomerulonephritis

Trial design

1,000 participants in 1 patient group

Acute kidney injury patients requiring renal replacement therapy

Description:

Critically ill adult patients with acute kidney injury undergoing any form of renal replacement therapy in Latin American hospitals